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Advanced / Aggressive Protocol (2 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)

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The downstream effects include increased adipose-tissue thermogenesis and reduced fat-storage gene-expression programs

By week 68, 88.2% of those assigned to combination therapy remained on treatment