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Replacement of Lys105 by uncharged residues in K105A/Y resulted in a 6597% decrease of the k cat app values for GSSCys and GSH (Fig

Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)

Edwin Lephart was not involved in the selection of peer reviewers for the manuscript or any of the subsequent editorial decisions