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Previous studies in myocardial ischemia have revealed that ischemia leads to a progressive loss of cholesterol from tissues and the sarcoplasmic and sarcoplasmic reticulum, accompanied by a significant increase in mitochondrial cholesterol content that is admixed explicitly to this membrane system [63]

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Must be used in controlled experimental settings by qualified professionals with proper training and credentials

When challenged with oxidative stress, VRK2 knockdown led to more cell death compared to the negative control group, and the increase in cell death could be mitigated by Ferr-1 (Fig