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References Australian Diabetes Society and Australian and New Zealand College of Anaesthetists
Compared to the common 3 isoform, the 4 variant is the strongest genetic risk factor for late-onset AD (Houlden et al., 1998), while the 2 isoform significantly reduces risk (Reiman et al., 2020)
Sci Rep 15 , 11158 (2025)
The crossover study of an oral methionine load by Bellamy et al (1998) also supports the view that elevated homocysteine levels may promote vascular disease by impairing flow-mediated endothelium dependent vasodilation
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