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Cascara Sagrada The bark of the buckthorn tree, known as cascara sagrada ( Rhamnus purshiana ) (UU 2015a), has traditionally been used to treat constipation
J Mol Neurosci 59(4):544553
It is released by intestinal L-cells after a meal and, separately, by preproglucagon neurons in the nucleus tractus solitarius of the brainstem, which gives the peptide both a peripheral endocrine role and a central neural one
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