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In reviewing recent drug-claim details for several large plan sponsors, we uncovered a growing number of GLP-1 claims being dispensed and paid for plan participants with no prior history of type 2 diabetes for plans that do not cover these weight-loss medications
Lower or more gradual dosing may improve tolerability for some patients, but it does not eliminate side effects or serious risks
Others cover weight-related use if you meet criteria like BMI above 30 or BMI above 27 with related conditions
Importantly, this work also revealed impaired synaptic pruning and ASD-like behavioral phenotype in mice lacking neuronal autophagy
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