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Skin whitening is classified as a drug claim (altering the structure or function of the body), not a cosmetic claimproducts marketed for this purpose require FDA approval as a drug, which glutathione does not have

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Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis