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This was inspired by prior GIP (glucose-dependent insulinotropic polypeptide) research, highlighting that besides GIP, other substances in the intestine also stimulate insulin secretion
Mazzarino M, Colpaert T, Deventer K, et al
Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)
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