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Activating upstream targets of the GSH system The key upstream target for GSH system modulation is generally considered to be Nrf2, a redox-sensitive regulator
It is also produced artificially in laboratories, using Cysteine, Glycine and Glutamic acid
Caveat: Contains some antioxidant compounds
Upon reperfusion, the abrupt ROS burst and the release of DAMPs recruit circulating monocytes and promote their differentiation into pro-inflammatory M1 macrophages
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