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What is more, insulin stimulates PDA cells to secret Shh (sonic hedgehog), IL-6, tissue growth factor (TGF) to promote fibroblast cell growth in TAM (Mutgan et al., 2018)
Compared with a placebo or non-user comparator, this design minimizes immortal time bias and confounding by balancing disease severity or treatment eligibility in two groups, providing a more reliable real-world estimate of relative effects
Concentration-wise, most serums land in the 1-2% range
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