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Combined with liposomal form, it is one of the most advanced supplementation methods available today

Since B12 is not created by the human body, it can be supplemented via this method if your diet is insufficient

The histidine residues provide a tertiary structural interaction with the two domains of PrP and copper, that is also protective in function due to involvement of the conserved central region of the protein (Roseman et al., 2020)

However, most therapeutic drugs are unable to enter the brain parenchyma to exert their effects due to the presence of the bloodbrain barrier (BBB), so more effective treatments need to be developed for central nervous system diseases