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Because tesamorelin stimulates GH production, patients receiving glucocorticoid replacement for previously diagnosed hypoadrenalism may require an increase in maintenance or stress doses following initiation of tesamorelin, particularly in patients treated with cortisone acetate and prednisone because conversion of these drugs to their biologically active metabolites is dependent on the activity of 11HSD-1
So patients with liver disease may have higher-than-normal baseline INRs
MTHFR and undermethylation: tested often, causal less often MTHFR affects production of 5-methyltetrahydrofolate, which helps remethylate homocysteine through methionine synthase
Sankey diagram showing the relationship between AML-8 and ELN classification
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