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Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden
BPC-157 and TB-500 are not TGA-approved therapeutic agents for general use in Australia.
Nature 586:785789
doi:10.1016/j.jmb.2008.06.083
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