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GI adverse events occur in 50 to 60 percent of patients at higher doses, making careful titration essential
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The side effects of GIP/GLP-1 receptor agonists are most commonly gastrointestinal with nausea, vomiting, diarrhoea, constipation, but similar in severity and frequency to GLP-1 agonists [9]
This multi-receptor mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist), and has been associated with pronounced reductions in body weight and improvements in metabolic parameters in early clinical studies
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