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Roles of hormones in taste signaling

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7 In 1993, a German laboratory confirmed what Engs paper had implied: exendin-4 was not merely structurally similar to GLP-1 it was a high-potency agonist at the human GLP-1 receptor, stimulating the same cAMP signaling cascade in insulin-secreting beta cells and amplifying glucose-induced insulin secretion

They are optimal for their insulinotropic effect exclusively when glucose levels are elevated, thereby providing the capacity to decrease plasma glucose while mitigating the risk of hypoglycemia