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When food is ingested, the human body releases a hormone called glucagon-like peptide-1 (GLP-1), which instigates the release of insulin in hyperglycemic states, reduces glucagon secretion in hyperglycemic or euglycemic (normal) states, and also slows stomach emptying, all of which modulate glucose homeostasis (2)

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Janumet: Package Insert / Prescribing Info Package insert / product label Generic name: sitagliptin and metformin hydrochloride Dosage form: tablet, film coated Drug class: Antidiabetic combinations Medically reviewed by Drugs.com

8): Restores insulin sensitivity and reduces adipose mass in obese mice (15 mg/kg, 4 weeks) [216]