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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

Fournier, L., de La Taille, T

These biomarkers elucidate underlying resistance mechanisms by identifying resistance-prone subpopulations, metabolic adaptations, and key microenvironmental cues