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Plasma from xCT-knockout mice contains a higher proportion of oxidised cysteine 179 and xCT expression is increased in many tumours, 180 pointing out its relevance in the context of cancer and eventually contributing for cancer metabolic rewiring

This trial was registered in ClinicalTrials.gov (NCT03171727)

A recent study shows that physical exercise decreases the reduced form of glutathione and if exercise is prolonged, has been shown to decrease total plasma and tissue glutathione content over time

Serial follow-up data in some patients show fibrosis progression based on non-invasive testing, highlighting need for close follow-up