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GLP-1 reduces appetite while glucagon increases energy expenditure, creating both reduced intake and increased output simultaneously
These substances contribute to insulin resistance, dyslipidemia, and systemic inflammationkey drivers of type 2 diabetes, cardiovascular disease, and metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD)
Some people experience insomnia or disrupted sleep on tirzepatide, which compounds daytime fatigue
This specificity comes from growth hormone direct lipolytic action on visceral adipocytes, which express higher concentrations of growth hormone receptors than subcutaneous fat cells
