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The synthesis of GSH is a two-step ATP-dependent enzymatic reaction
Providers reserve these tiers for patients who have demonstrated consistent tolerability and who may benefit from additional metabolic effect based on their individual treatment goals
Treatments are usually administered over several weeks to gradually restore NAD+ levels while supporting metabolic balance
Notably, CT-388's weight loss curve had not plateaued at 48 weeks, suggesting the final treatment effect could be even higher at 72 weeks in the Phase III program
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