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Women tend to have lower creatine stores than men
10.1016/j.bioeng.2006.05.020 16
The mechanism is only partially understood but involves reduction of gene and protein expressions of fibrotic and inflammatory markers such as TGF-, TNF-, IL-2, MMP-9, vimentin and enhancement of antioxidant ability by increment of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and by preservation of mitochondrial function [215]
[1] [26] This reduces the risk of hypoglycaemia, though this risk increases significantly when used in combination with insulin or sulfonylureas, which may require dose reduction of these medications
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