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Abbreviations T2DM: Type 2 diabetes mellitus BA: Bile acid FXR: Farnesoid X receptor TGR5: G-protein-coupled bile acid receptor 5 CDCA: Chenodeoxy cholic acid CA: Cholic acid CYP7A1: Cholesterol 7 -hydroxylase C4: -Hydroxy-4-cholesterol-3-one CYP8B1: Cholesterol 12 -hydroxylase CYP27A1: Cytochrome P450 family 27 subfamily A member 1 BSEP: Bile salt export pump MRP2: Multidrug resistance-associated protein 2 ASBT: Apical sodium-dependent bile acid transporter MRP3: Multidrug resistance-associated protein 3 IABP: Ileal bile acid binding protein OST /OST : Organic solute transporter / NTCP: Sodium-dependent taurocholate cotransporting polypeptide OATP: Organic anion transporter DCA: Deoxycholic acid LCA: Lithocholic acid BSH: Bile salt hydrolase UDCA: Ursodeoxycholic acid TCA: Taurocholic acid HOMA-IR: Homeostatic model assessment of insulin resistance MAFG: Musculoaponeurotic fibrosarcoma oncogene family protein G GLP-1: Glucagon-like peptide 1 AMPK: AMP-activated protein kinase SG: Sleeve gastrectomy FGF15/19: Fibroblast growth factor 15/19 RYGB: Roux-en-Y gastric bypass Gly-MCA: Glycine--muricholic acid SHP: Small heterodimer partner LXR: Liver X receptor LRH-1: Liver receptor homologue-1 HNF-4: Hepatic nuclear factor-4 G6Pase: Glucose-6-phosphatase PEPCK: Phosphoenolpyruvate carboxylate kinase ChREBP: Carbohydrate response element binding protein FXRIN: Intestinal-specific FXR knockout mice FXRL: Liver-specific FXR knockout mice ER: Endoplasmic reticulum PKA: Protein kinase A cAMP: Cyclic adenosine monophosphate DIO2: Type II iodothyronine deiodinase PGC1-: Peroxisome proliferator-activated receptor-gamma coactivator 1- FGFRs: Fibroblast growth factor receptors JNK/ERK: C-Jun amino terminal kinase/extracellular signal regulated kinase KLB: -Klotho PXR: Pregnane X receptor CAR: Constitutive androstane receptor VDR: Vitamin D receptor TAS2R: Taste 2 receptor References Israili ZH

Experts say that the next generation of drugs may help achieve longevity or anti-ageing goals for millions around the world