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is defined as a proportionality constant that relates the total amount of drug present in the body at a specific time to the concentration of the drug measured in the plasma

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PDB codes of previously published structures used in this study are 4HJE (human p53 DBD), 3L2C (human FOXO4 FH domain bound to DNA) and 1E17 (human FOXO4 FH domain)

Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus