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A systemic review and meta-analysis
Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit
Across all trials, a total of 22 participants experienced severe hypoglycaemia, defined as an event requiring assistance: ten with tirzepatide ( n = 4414)
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