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Nature 583 (7816), 441446
Dose escalation planning: Anticipate steady-state changes when transitioning to higher maintenance doses during titration
We further validated the existed difference in glycolysis levels between grade IV IDH1 mutant and GBM in both male and female patient groups in CGGA325 and CGGA693 cohorts, which indicates the difference in glycolysis levels caused by IDH1 mutation status independent of sex (Supplementary Fig
It appears to bind to p53 and thereby may prevent apoptotic death of the senescent cells
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