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The SURMOUNT-1 trial for tirzepatide and the STEP-1 trial for semaglutide are the most comparable datasets, both running over 68 to 72 weeks with similar patient populations
Modifications introduced during synthesis can alter charge distribution and shift the isoelectric point in ways that are not always immediately obvious from the sequence alone
Use of these drugs peaks in middle age, then falls off a cliff right at 65
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