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Oxidative stress, marked by increased ROS production and GSH consumption, is implicated in various neurodegenerative and neuropsychiatric disorders such as Parkinsons disease, Alzheimers disease, multiple sclerosis, and schizophrenia 4,5
This impairs Notch2 degradation and sustains oncogenic Notch2 signaling, which upregulates c-Myc and Cyclin D3 expression
The overexpression of GSTs in cancer cells offers unique opportunities for prodrug therapy 108
It was conducted at Seoul National University (one of Asia's top research institutions) with full IRB ethical approval
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