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Initial changes in skin hydration and surface texture typically appear between weeks 2 and 4
Alternative markers such as cystatin C-based eGFR or enzymatic creatinine assays may provide more accurate assessment when clinical concern exists, as recommended in KDIGO guidelines
At the two tested concentrations, treatment with both GHK and GHK-Cu did not significantly increase the IL-1, IL-8 and HSPA1A protein levels
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