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In fact, many report that it feels like a switch has been flipped
This dual mechanism is significant because, as mentioned earlier, tirzepatide maintained anti-inflammatory effects even when neuronal GLP-1 receptors were knocked out in animal models
Participants maintaining the highest 12 mg dose of retatrutide lost an average of 30.3% of their body weight (38.5 kg) at 104 weeks, while those moving from the lowest 4 mg dose to the maximum tolerated dose lost an average of 27.9% of their body weight (33.2 kg)
On a GLP-1, the direction worth watching is a steep drop, which usually points back to not eating enough protein
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