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If twice daily, then administer once in the early morning, two hours prior to breakfast, and once in the evening, two hours following the subjects meal

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P., Sablonniere, B., Guieu, R., et al

The most important unresolved safety-related research gaps include long-duration exposure, broader dose-response toxicology, sex-specific effects, reproductive and developmental endpoints, hematology, immune monitoring, genotoxicity assessment, and comprehensive off-target profiling across methyltransferase and non-methyltransferase targets