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The resulting active compounds cause damage to the cells in the lining of the intestine and leads to apoptosis (a form of cell death)
We therefore next investigated the potential involvement of SPHKAP in GLP-1R signal transduction from ERMCSs
Sinomenine is an active alkaloid from Sinomenium acutum , and its derivative facilitates interactions between nuclear receptor coactivator 4 (NCOA4) and FTH1, accelerating Fe 2+ release and ultimately promoting ferroptosis in colon cancer cells (Zhu et al., 2024)
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