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Oral supplements have to pass through the digestive system and may not be absorbed efficiently, especially in people with gastrointestinal conditions like celiac, Crohns, or gastritis

125 Bacterial or viral infection is a common trigger for COPD exacerbations, and exposure to LPS induces p38MAPK activation in rat peritoneal macrophages and dendritic cells as well as an increase expression of inflammatory mediators

Because it activates three receptor pathways, the dose-response curve is steeper and the side effect profile is more sensitive to sudden increases