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Individual results vary based on skin condition, metabolism, wellness goals, existing pigmentation concerns, and adherence to the recommended treatment plan

Table of Contents How DPP-4 Inhibitors Work to Reduce Blood Sugar Levels Expected HbA1c Reductions With DPP-4 Inhibitor Treatment Comparing DPP-4 Inhibitors to Other Type 2 Diabetes Medicines NICE Guidelines on Using DPP-4 Inhibitors in Type 2 Diabetes Factors That Affect How Well DPP-4 Inhibitors Lower HbA1c Side Effects and Safety Considerations for Patients Scientific References Frequently Asked Questions How DPP-4 Inhibitors Work to Reduce Blood Sugar Levels DPP-4 inhibitors block the enzyme that degrades incretin hormones GLP-1 and GIP, increasing insulin secretion and reducing glucagon release in a glucose-dependent manner, which limits hypoglycaemia risk when used alone or with metformin

Most reactions resolve spontaneously upon continued use or dose adjustment

Acknowledgments The authors acknowledge the infrastructure and staff support provided by the School of Biomedical Sciences and CHRI, Faculty of Health Sciences Curtin University