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Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH

That removes preparation variance as a confounder when comparing results across components

In addition to powering the New Mayo Clinic Diet, Digital Wellness works with pharmaceutical companies, corporations, and the government to provide chronic disease management programs.

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