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Interestingly, a correlation has been discovered between the augmentation of angiogenesis and lymphangiogenesis in the sentinel lymph node (SLN), the first TDLN in which cancer cells from the primary tumor appear, and the occurrence of distant metastasis, as well as the survival outcomes of melanoma patients (167)
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RSL3 is able to induce ferroptosis by directly inhibiting the enzymatic activity of GPX4 through covalent interaction with selenocysteine at the active site of GPX4 (51)
It has a molecular formula of CHCuNO, a molecular weight of 403.92 g/mol, and a CAS number of 49557-75-7
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