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Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes

RI at a dose of 10 mg produced significant enhancement in GPx (138 %) and GST (144 %) enzymes, and no significantly changes in GSH and GR parameters

Three patients with BRIC-1 had compound heterozygous variant in the ATP8B1 gene and 1 had heterozygous while 2 patients with BRIC-2 had compound heterozygous in the ABCB11 gene and 1 had heterozygous