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Description

Characterization of stable and reactive metabolites of piperine formed on incubation with human liver microsomes

2018 Oct;20(10):1228

Blocking glutathione synthesis abolished the effect, while exogenous glutathione replicated it, confirming the mechanism (Babu et al., 2001)

The most commonly observed adverse events (incidence of 5% and twice that of placebo) were oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation and fecal incontinence