We have previously demonstrated an increased nicotinamide:nicotinic acid ratio in the adipose tissues of 5A-1MQ-treated DIO mice 13
However, these figures are likely underestimates due to significant diagnostic challenges
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Since synergy demands a higher standard than simple overlap, its evaluation requires comparisons between combinations and individual peptides, standardized injury models, and predefined evaluation criteria (migration assays, histology, collagen organization, vascular markers, inflammatory markers, and functional metrics)
