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Some patients report improved mood and reduced anxiety once weight loss begins, likely due to reduced metabolic stress

Other AEs reported with SGLT2i use include osmotic diuresis-related events and volume depletion-related hypotension, the latter of which tends to be more common in older adults, people with an eGFR of 3060 mL/min/1.73 m 2 , and in those taking loop diuretics [4]

Other exclusion criteria included cardiac/respiratory failure, or prior beta-blocker use for variceal bleeding

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