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Semaglutide 7,2 mg in adults with obesity STEP UP
Pioglitazone in combination with vitamin E improved liver histology in patients with NASH and T2D (ClinicalTrials.gov NCT01002547)
(They excluded those who had known mental health diagnoses prior to taking the drug.) That raises the question of whether the drug has a different effect, or additional effects, on those with a pre-existing mental health condition
Both use a gradual dose escalation to minimize GI side effects, sharing the same schedule through 1.0 mg before diverging
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