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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

For example, peptides, especially when injected, may trigger severe immune responses

We observe that people predicted to achieve higher weight loss did indeed achieve higher weight loss in the longitudinal EHR data (Fig