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250,251,252 UA induced inflammation and relative mechanism Uric acid signaling triggers the activation of several transcription factors, such as NF-B or AP-1, through the activation of MAPK p38 and ERK pathways, resulting in the production of reactive oxygen species (ROS) under the conditions of hyperuricemia
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My commentary - this discussion needs to go deeper
AD Cognitive impairment in AD is closely associated with disrupted iron homeostasis, excessive oxidative stress and the accumulation of A and tau proteins, which collectively promote ferroptosis
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