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In the hindbrain, the dorsal-vagal-complex (DVC), collectively comprised of the nucleus tractus solitarius (NTS), area postrema (AP) and dorsal motor nucleus of the vagus (DMV), mediates the anorectic effects of both amylin and GLP-1 receptor agonists 15,16,17,18,19
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- In SURMOUNT-2, people taking Zepbound at the 15 mg dose experienced average weight reductions of 15.7% (34.4 pounds) and people taking Zepbound at the 10 mg dose experienced average weight reductions of 13.4% (29.8 pounds) compared to placebo 3.3% (7.0 pounds)
A central finding is that gradual dose escalation measurably reduces the frequency and severity of these events
Knowing ahead of time who is likely to respond would help patients get on the right drugs faster a step toward precision medicine, Gloyn said
