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The FDA resolved the semaglutide and tirzepatide shortages in 2025, ending the broad shortage-based pathway that powered large-scale compounding, and in April 2026 proposed excluding these drugs from the 503B bulks list, with a comment period through June 29, 2026
Where you inject your GLP-1 agonist affects how quickly the drug reaches peak plasma levels, which in turn affects the timing of both therapeutic effects and side effects
Key points The results of the EMPA-REG OUTCOME trial fundamentally transformed cardiovascularkidneymetabolic medicine by demonstrating that a glucose-lowering drug (a sodiumglucose cotransporter 2 (SGLT2) inhibitor) could reduce cardiovascular death, hospitalization for heart failure and the progression of chronic kidney disease in patients with type 2 diabetes mellitus
Over the last 6 years, I have spent more money on blood tests than drugs
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