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An estimated ~1100 nuclear-encoded proteins are required for mitochondria-specific pathways in a tissue- and cell-type specific manner, with nuclear and mitochondrial OXPHOS subunits requiring strict coordination and stoichiometric expression 6
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The practical implication is straightforward: a dose that feels tolerable for a man may be genuinely too much for a woman of equivalent weight
Vicente-Snchez A, Snchez-Blzquez P, Rodrguez-Muoz M, Garzn J
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