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Your healthcare team can assess whether a dietary modification, dose adjustment, or medication change is appropriate
A 2020 preclinical toxicity review found no serious toxicity in mice, rats, rabbits, or dogs at tested doses, but longterm human carcinogenicity or organtoxicity data are missing
however the ongoing CAROLINA trial was designed to compare the CV effects of linagliptin to glimeperide as active comparator and will soon (second half of 2018) provide valuable information regarding the impact of DPP-4 inhibition in diabetic CV outcomes [27, 31, 32]
They're not just gut hormones, like you said, they're neurotransmitters and they're body-wide receptors waiting to be activated, so it's wild
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