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Until now, there has been a contradiction between the importance of this major target for anti-diabetic and anti-obesity drugs, and the importance of mutations in this target gene in humans
For tirzepatide, about 80%
However, other GLP-1 analogues used either as monotherapy or in combination with other drug classes have the potential to encourage additional weight loss in people with obesity [26], but are currently not licensed for this use and are licensed for use in T2D alone
doi: 10.2337/dbi21-0006 5 ZammouriJVatierCCapelEAuclairMStorey-LondonCBismuthEet al
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