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Semaglutide and tirzepatide primarily target GLP-1 receptors, with tirzepatide adding GIP receptor activation

Modulating level control (Figure 8.3.2) The final control element may be a valve that is adjusted to a point between fully open and fully closed, as a function of the level being monitored

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MariTide (Amgen) is a once-monthly injectable that acts as a GIP antagonist combined with a GLP-1 agonist, showing roughly 12% to 16% weight loss in Phase 2 and now in Phase 3