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These drugs were first approved in diabetes under brand names Ozempic and Mounjaro, respectively

Ongoing investigations in our laboratory and clinical program aim to further substantiate this surprising observation in MDS and in clonal hematopoiesis of indeterminate significance (CHIP) and in clarifying the mechanism behind these effects. Further analysis of prospective cohorts with serial biospecimens would be advantageous to understand the potential connection between GLP-1 exposure and inflammasone markers and how this could influence ROS and DNA damage

MO is supported by the Arthritis Society through a STAR/IMHA award (award 00049)

But unlike systemic anabolic signals from testosterone or growth hormone, IGF-1 DES creates localized hyperplasia (i.e