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Pre-existing neuropathy The case of the 75-year-old man with baseline neuropathy who developed severe allodynia on tirzepatide suggests that pre-existing nerve damage may create vulnerability
However, no stable differences were observed for HOMA-IR or total cholesterol, suggesting that while benefits for weight, lipid metabolism, and androgens are relatively consistent, the IR endpoint may be more heavily influenced by sample size, follow-up duration, and baseline IR severity
[1] [14] Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications approved for type 2 diabetes management and, more recently, for chronic weight management
Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma
